Long-Term Outcomes in Neurosarcoidosis

To identify prognostic factors in neurosarcoidosis (NS) and to examine the effectiveness of immunosuppressive agents in reducing risk for relapse of the disease, French investigators conducted a single-center, retrospective cohort study involving 234 NS patients (median age at diagnosis, 42 years), 70% of whom had multisystem involvement. Presentations included encephalitis in 56%, myelitis in 27%, cranial neuropathy in 37%, radiculoneuropathy in 10%, and myositis in 8%. Electrophysiologic studies confirmed peripheral nerve abnormalities in 57% and muscle involvement in 18% of patients studied.

Overall survival at 10 years was 89%. Unfavorable survival outcomes were associated with older age, involvement of the peripheral nervous system, and…