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Several years ago, a compelling study from Mayo Clinic cast doubt on the existence of clinically important nephropathy from intravenous (IV) contrast given for computed tomography (CT; NEJM JW Gen Med May 1 2014 and Radiology 2014; 271:65). However, there is still considerable resistance to performing contrast-enhanced CT in patients with impaired renal function. In 2017, two new studies reinforced the earlier findings.
The same Mayo researchers conducted another study, in which 1500 patients with varying degrees of renal insufficiency who underwent contrast-enhanced CT (with the iso-osmolar agent iodixanol) were compared with propensity-matched patients who underwent noncontrast CT. Regardless of baseline renal function, rates of acute kidn…