Declining Prevalence of Clostridium difficile BI/NAP1/027 Strain in the U.S.

A retrospective survey among Veterans Affairs medical centers indicates declining prevalence for this hypervirulent strain associated with the most severe forms of C. difficile infection.

Clostridium difficile is responsible for one quarter of antibiotic-associated diarrhea and is the most common healthcare-associated infection. The rates of C. difficile infection (CDI) dramatically increased in the past two decades, with more-severe courses and increased mortality. A considerable proportion of these infections are attributable to the hypervirulent and more toxigenic C. difficile strain “BI/NAP1/027” (restriction endonuclease analysis pattern, BI; pulsed-field gel electrophoreses pattern, NAP1; PCR ribotype designation, 027). However, data on the recent epidemiology of CDI have been lacking so far for the U.S. A retrospective, observational, nationwide study, performed from June 2011 through June 2016 in 128 VA Network hospi…

Reviewing Author

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Thomas Glück, MD

Disclosures

Editorial BoardsConsilium Infectiorum by InfectoPharm, Infection

Declining Prevalence of Clostridium difficile BI/NAP1/027 Strain in the U.S.

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Reviewing Author