Symptomatic Acute HIV Infection Linked to Greater Immune Damage

Acute retroviral syndrome was seen in 78% of persons with primary infection and was associated with higher initial HIV levels and persistent immune impairment.

Most patients with primary HIV infection experience an acute retroviral syndrome (ARS). In this study, investigators prospectively identified newly infected HIV persons who then underwent clinical and laboratory assessment and were offered immediate antiretroviral therapy (ART). The study was conducted in Bangkok, Thailand, among persons presenting for voluntary HIV testing with a 4th generation immunoassay (IA) that detects HIV antigen, IgG, and IgM. Negative samples underwent pooled nucleic acid testing (NAT); reactive samples underwent 2nd generation IA that detects HIV IgG only. Acute HIV infection was diagnosed in patients with a negative 4th generation IA and positive NAT or reactive 4th generation IA and non-reactive 2nd generation I…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Symptomatic Acute HIV Infection Linked to Greater Immune Damage

Topics

Reviewing Author