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Tumor-treating fields (TTFields) are a new electrical-field therapy being used to target mitotically active tumor cells, arrest growth, and induce apoptosis in patients with glioblastoma. TTFields are delivered continuously by a transducer array, which is similar to an electroencephalography electrode cap and is worn on a shaved scalp.
A prior planned interim analysis of an industry-funded, multicenter, open-label, randomized, phase III study (EF-14) showed that adding TTFields to maintenance temozolomide chemotherapy significantly prolonged survival in 315 patients with newly diagnosed glioblastoma (NEJM JW Neurol Feb 2015 and JAMA 2015; 314:2535). Investigators now report final results of the EF-14 study, which includes 695 patients who re…