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Probiotic therapy has shown promise in helping infants with colic, but randomized, controlled trials have produced conflicting results. These researchers performed an individual participant data meta-analysis involving 345 infants with colic enrolled in four randomized, controlled trials that measured the effect of Lactobacillus reuteri DSM17938 versus placebo on crying/fussiness. Outcomes were duration of crying/fussiness and treatment success (≥50% reduction in crying/fussiness time from baseline) measured at 7, 14, and 21 days. All four trials included breast-fed infants, while only one included formula-fed infants. The trials were conducted in Italy, Poland, Canada, and Australia.
In pooled analysis, the probiotic group had significantly…