Does Hydrolyzed Formula Reduce Risk for Type 1 Diabetes in Infants at Risk?

After 11.5 years of follow-up, the incidence of type 1 diabetes did not differ between infants fed hydrolyzed casein-based formula and those fed conventional cow's milk–based formula.

Proposed interventions to prevent or delay the autoimmune response that leads to type 1 diabetes include reducing early exposure to complex antigens. In an international multicenter trial, 2159 infants at risk for type 1 diabetes (risk-conferring HLA genotype and at least 1 first-degree relative with diabetes) were randomized to be weaned to either an extensively hydrolyzed casein-based formula or conventional cow's milk–based formula for at least 60 days and up to 6 months. The investigators previously reported findings at 7 years: hydrolyzed casein formula did not prevent or delay development of islet cell autoantibodies (NEJM JW Pediatr Adolesc Med Aug 2014 and JAMA 2014; 311:2279). Now they report outcomes at 11 years.

Study formula was …

Reviewing Author

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

F. Bruder Stapleton, MD

Disclosures

Consultant/Advisory BoardCareer Physician

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesAmerican Society of Pediatric Nephrology Foundation (Chair)

Does Hydrolyzed Formula Reduce Risk for Type 1 Diabetes in Infants at Risk?

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Reviewing Author