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Most adverse events during endoscopy are due to sedation. To prospectively assess risk for complications during endoscopy, researchers analyzed data from more than 350,000 endoscopies conducted across dozens of centers in Germany.
Sedation was used in 89% of procedures. Propofol alone was used in 62% and propofol in combination with midazolam in 23%. Half of the procedures were done with two-person teams and the other half with three-person teams in which one person was responsible only for sedation. Results were as follows:
Major complications occurred in 0.01% and minor complications in 0.3% of patients with sedation, compared with 0.007% and 0.05%, respectively, in unsedated patients.
Mortality was 0.004% with sedation and 0.002% without se…