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In 2016, a new definition of sepsis (Sepsis-3) was proposed, which abandoned use of the systemic inflammatory response syndrome (SIRS) criteria (NEJM JW Gen Med Mar 15 2016 and JAMA 2016; 315:775) and introduced a new prognostication tool, the quick Sequential Organ Failure Assessment (qSOFA). During the past 2 years, investigators have made numerous attempts to assess qSOFA.
In a meta-analysis of 38 studies, investigators examined the effect of qSOFA screening on emergency department (ED) patients, inpatients, and intensive care unit (ICU) patients with suspected infection. Most studies (63%) were retrospective analyses, and most reported ED use of qSOFA. No randomized controlled trials of qSOFA have been published.
qSOFA's pooled sensitivit…