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In 2016, a widely publicized study from Germany suggested a link between use of proton-pump inhibitors (PPIs) and dementia (NEJM JW Gen Med Jun 15 2016 and JAMA Neurol 2016; 73:410), but several methodologically stronger studies in 2017 failed to confirm this link (NEJM JW Gen Med Jan 1 2018). Now, yet another report — in which Seattle researchers took advantage of a prospective population-based cohort study within an integrated healthcare delivery system — has addressed this issue.
Nearly 3500 older patients (age, ≥65) were evaluated formally for dementia every 2 years. Pharmacy data for the previous 10 years were available to calculate PPI exposure (the health plan covered prescription PPIs even after these drugs became available over-the-…