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Many physicians review patient-collected blood pressure (BP) readings when titrating antihypertensive medications, but evidence supporting this approach has been mixed. British researchers randomized 1182 patients with uncontrolled hypertension (office BP, ≥140/90 mm Hg, despite as many as 3 antihypertensives) to usual care (clinic BP readings), self-monitoring (twice-daily BP readings for 1 week each month mailed in; instructions to contact the physician for very high or very low readings), or telemonitoring (twice-daily BP readings for 1 week, submitted via monthly text messaging; prompts to contact the physician for very high or very low readings or elevated average BPs).
At baseline, mean office-measured systolic BP was ≈153 mm Hg in all three groups. After 12 months, mean office-measured systolic BP was significantly lower with self-monitoring and telemonitoring than with usual care (137.0, 136.0, and 140.4 mm Hg, respectively); diastolic BPs remained similar in all three groups. The differences in systolic BP appeared to be driven by a significantly greater number of medications prescribed to the intervention groups than to the usual-care group.
McManus RJ et al. Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4): An unmasked randomised controlled trial. Lancet 2018 Mar 10; 391:949. (https://doi.org/10.1016/S0140-6736(18)30309-X)
Rietzschel ER and De Buyzere ML.Hypertension: Time for doctors to switch the driver's seat? Lancet 2018 Mar 10; 391:914. (https://doi.org/10.1016/S0140-6736(18)30317-9)
Comment
Although this study was not powered for clinical endpoints, the differences in systolic BP could translate into substantially fewer adverse cardiovascular events. Further research should help refine self-monitoring to maximize its efficacy and cost-effectiveness.