Long-Term PPI Use Not Associated with Hip Fractures

Data are inconsistent regarding any association between use of proton-pump inhibitors (PPIs) and risk for bone fractures. To evaluate this potential relation, investigators used a nationwide Finnish database to perform a nested case-control study in community-dwelling patients with Alzheimer disease. Some 4800 patients with incident hip fractures were identified and matched to 19,000 controls without hip fractures (mean overall age, 84; 75% women). Data on PPI use were obtained from a nationwide prescription register.

Neither long-term (>1 year) nor cumulative PPI use was associated with excess risk for hip fractures — and current use showed a very small association that barely achieved statistical significance (odds ratio, 1.12; 95% confide…