A Computer Model to Reduce Hospital-Acquired Clostridium difficile Infection

An agent-based simulation showed that daily room cleaning and screening for colonization at admission were the most effective interventions.

The clinical and economic impacts of hospital-onset Clostridium difficile infection (HO-CDI) have continued to worsen. To reduce the rates of HO-CDI, hospitals have implemented bundles of discrete interventions, but these may vary considerably in composition, strength of evidence, and effectiveness.

In a prior study, investigators developed an agent-based computer model to assess the effectiveness of specific interventions within bundles to reduce HO-CDI (Med Decis Making 2015; 35:211). The researchers have now developed a model of HO-CDI interventions in a hypothetical 200-bed acute-care hospital based on the recent literature on HO-CDI epidemiology, diagnosis, and preventive interventions.

Six interventions were associated with a reduction …

Reviewing Author

Neil M. Ampel, MD

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Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

Neil M. Ampel, MD

Disclosures

Editorial BoardsUpToDate

Leadership Positions in Professional SocietiesCoccidioidomycosis Study Group (Past President, Secretary, Treasurer)

A Computer Model to Reduce Hospital-Acquired Clostridium difficile Infection

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Reviewing Author