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Secondary progressive multiple sclerosis (SPMS) is an MS subtype characterized by worsening of disability that begins insidiously in patients with preceding relapsing-remitting (RR) course, which is the most common mode of onset. The risk for and timing of transition from RRMS to SPMS is unpredictable; however, up to 90% of RRMS may evolve to SPMS over a 25-year time interval. Several disease-modifying therapies have shown efficacy in reducing relapses and disease activity in RRMS, but most of these have failed to prevent disease worsening in progressive MS.
This multicenter, randomized, double-blind, placebo-controlled, manufacturer-funded phase 3 study was done at almost 300 hospital clinics and specialized MS centers in 31 countries. Rese…