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Although pyoderma gangrenosum is uncommon, busy generalist clinicians likely will encounter cases of this ulcerating cutaneous disorder on occasion. In a retrospective study that involved 356 patients from three U.S. academic medical centers, researchers describe the prevalence of diseases associated with pyoderma gangrenosum. The authors believe that this is the largest published case series.
Mean patient age was 52, 32% were older (age, ≥65), and 75% were women. Associated diagnoses were Crohn disease (26%), inflammatory arthritis (21%), ulcerative colitis (15%), malignancy (12%; evenly divided between solid-organ and hematologic cancers), hidradenitis suppurativa (6%), and other hematologic disorders such as myelodysplasia (5%). One third…