Thrombi on Left Atrial Appendage Occlusion Devices in a Real-World Registry

In a French registry, thrombus was common and associated with ischemic stroke.

In a retrospective registry study, investigators analyzed the incidence, predictors, and prognosis of thrombus formation on two devices for left atrial appendage occlusion (LAAO) at eight French centers between 2012 and 2017. The study included 487 consecutive patients (mean age, 75; 61% men); 469 successfully received LAAO devices.

Medications at discharge included oral anticoagulation (OAC) in only 34% of patients; 59% received antiplatelet agents without OAC, and <8% received none. At a mean follow-up of 13 months, imaging with transesophageal echocardiography or computed tomography was performed in 339 patients (72%). Thrombus was detected on the device in 26 patients (yearly rate, 7.2%), 10 of whom had been discharged on OAC. In multiva…

Reviewing Author

Howard C. Herrmann, MD

Disclosures

Consultant/Advisory BoardAffluent Medical; Artedrone; Caranx; Johnson & Johnson; Medtronic; Prolifagen; Wells Fargo

EquityMicrointerventional Devices, Inc.

RoyaltiesUniversity of Pennsylvania

Grant/Research SupportAbbott Vascular; Edwards Lifesciences; Johnson & Johnson; Medtronic

Editorial BoardsCatheterization and Cardiovascular Interventions; Journal of the American College of Cardiology; Circulation: Cardiovascular Interventions; JACC Cardiovascular Interventions; JACC Case Reports; JSCAI

Leadership Positions in Professional SocietiesHeart Valve Collaboratory (Scientific Committee Member, Chair of the Publications Committee)