Probiotics for Mania

In a placebo-controlled study, patients taking a specific combination of probiotics had fewer and shorter rehospitalizations.

The microbiome has important roles in inflammatory response and neurologic functioning. Because some patients with acute mania have elevated levels of inflammation, these researchers tested the effects of a probiotic combination on relapse in patients recently discharged following hospitalization for mania.

In the double-blind study, 66 patients continued their medication regimens and were randomized to receive 24 weeks of either Lactobacillus rhamnosus strain GG plus Bifidobacterium animalis subsp. lactis strain Bb12 or placebo. An inflammation score, calculated at baseline, was developed from four measures — immunoglobulin G (IgG) class antibodies to the NR2 peptide fragment of the NMDA receptor; IgG class antibodies to gliadin; IgG class …

Reviewing Author

Jonathan Silver, MD

Disclosures

RoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions

Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience

Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)

Jonathan Silver, MD

Disclosures

RoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions

Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience

Probiotics for Mania

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Reviewing Author