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The best way to combine and sequence antidepressant medication and cognitive-behavioral therapies to optimize long-term outcomes for depressed patients remains unclear. To learn more, researchers conducted a randomized, controlled trial involving 289 depressed subjects who had at least two depressive episodes, who were taking antidepressants (mostly selective serotonin reuptake inhibitors) for at least 6 months, and who were remitted for 2 months up to 2 years.
Participants were randomized to continue medication, receive preventive cognitive therapy (PCT; 8 weekly sessions) plus tapering of antidepressants over 6 months, or receive PCT with continued antidepressants. In a survival analysis examining relapse outcomes through 24 months, PCT pl…