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Antidepressants are associated with weight gain in the short term, but little is known about their long-term effects. In this population-based cohort study, U.K. researchers determined the long-term associations between antidepressant prescriptions and weight gain in about 300,000 patients who had three or more body-mass index measurements between 2004 and 2014.
In the year of study entry, 13% of men and 22% of women were prescribed antidepressants. During average follow-up of 6 years, the incidence of ≥5% weight gain was significantly higher in participants who were prescribed antidepressants than in those who were not (11.2 vs. 8.1 per 100 person-years). Initially normal-weight participants who took antidepressants were more likely to beco…