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Cerebral microbleeds can be detected on brain MRI using sequences such as susceptibility-weighted imaging. Microbleeds are thought to represent small-vessel vasculopathy and are often found in patients with poorly controlled hypertension or cerebral amyloid angiopathy (CAA). Microbleeds can also be associated with cognitive impairment. For patients with atrial fibrillation (AF) who require oral anticoagulation medication after ischemic stroke, does the presence of microbleeds alter the risk/benefit ratio? To find out, researchers recruited patients with AF and a recent stroke or transient ischemic attack at 79 European centers and tracked outcomes for 24 months. The primary outcome was symptomatic intracranial hemorrhage (ICH).
Of 1490 patie…