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The management of patients with ischemic strokes usually includes aspirin to inhibit platelet function and prevent recurrences. However, some individuals might remain at risk because their platelets are relatively resistant to the inhibitory effects of aspirin.
To determine whether platelet function testing identifies patients at risk for ischemic vascular events despite aspirin therapy, investigators at a single center examined 805 patients with acute ischemic strokes. All patients received a 300 mg aspirin loading dose, followed by daily maintenance doses of 100 mg. Platelet function analysis was performed 3 hours after the loading dose and repeated on day 5. Values ≥550 IU at either time point defined aspirin resistance. The primary outco…