Longitudinal data strengthen the association between these medications and impulse control disorders.
Impulse control disorders (ICDs), including compulsive sexual behavior, gambling, shopping, and eating, have been reported to occur in patients with Parkinson disease who are treated with dopamine agonists (DAs). These researchers examined data from a longitudinal cohort study in France to determine links between these medications and ICDs in 411 Parkinson disease patients (mean age, 62; 41% women).
Annual semistructured interviews included assessment of symptoms of dopaminergic dysregulation (compulsions). During the mean follow-up of 3.3 years, 356 participants (87%) used a DA at least once. In analyses of participants without an ICD at baseline, 52% of 260 ever-users of DAs developed an ICD vs. 12% of 46 never-users. ICDs gradually resolv…
Reviewing Author
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)