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Robot-assisted surgery has become routine in the management of prostate and renal cancers and is increasingly used in muscle-invasive bladder cancer, although the data available regarding outcomes and morbidity are less robust. To address this gap, investigators conducted a multicenter, noninferiority, randomized phase III study involving 350 patients with T1–T4, N0–N1, M0 bladder cancer who underwent open or robot-assisted cystectomy. All participating surgeons were either fellowship trained or had a focused practice in bladder cancer. The urinary diversion was done extracorporeally according to patient and surgeon preference.
Two-year progression-free survival (the primary endpoint), was 72.3% with robot-assisted cystectomy and 71.6% with …