Long-Term Risk for Gout, According to Baseline Uric Acid Levels

Fifteen-year risk ranged from 1% (with levels <6 mg/dL) to 49% (with levels ≥10 mg/dL).

Elevated uric acid levels are a key risk factor for developing gout. However, the actual frequency of gout attacks relative to uric acid concentration is variable. In this analysis of individual patient data from four cohorts, investigators examined the relation between serum uric acid concentrations and clinically evident gout. These longitudinal studies included data on incident gout (with gout defined by classification criteria, patient report, or physician diagnosis), serum urate levels (measured prior to incident gout), and follow-up for a minimum of 3 years. Almost 19,000 participants were gout free at study onset; mean follow-up was 11.2 years.

At 5 years, the incidence of gout rose, in a concentration-dependent manner, from 0.33% (fo…

Reviewing Author

Jonathan S. Coblyn, MD

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Consultant / Advisory BoardCVS Health

Editorial BoardsUpToDate

Jonathan S. Coblyn, MD

Disclosures

Consultant / Advisory BoardCVS Health

Editorial BoardsUpToDate

Long-Term Risk for Gout, According to Baseline Uric Acid Levels

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Reviewing Author