Early Renal Replacement Therapy in Acute Respiratory Distress Syndrome and Sepsis?

Early RRT did not lower mortality in patients with acute kidney injury associated with ARDS or septic shock.

Two previous studies about timing of initiation of renal replacement therapy (RRT) for critically ill patients with acute kidney injury (AKI; NEJM JW Gen Med Jul 15 2016 and JAMA 2016; 315:2190 and N Engl J Med 2016; 375:122) yielded conflicting results. A single-center trial showed benefit, while a multicenter study did not. Subsets of the studied populations might have had different responses to the timing of RRT. For example, in patients with acute respiratory distress syndrome (ARDS) or septic shock, early fluid removal could result in faster liberation from mechanical ventilation and early clearance of inflammatory cytokines might help reverse vasodilation.

To address this distinction, investigators from the multicenter trial conducted …

Reviewing Author

Patricia Kritek, MD

Disclosures

Editorial BoardsATS Scholar

Patricia Kritek, MD

Disclosures

Editorial BoardsATS Scholar

Early Renal Replacement Therapy in Acute Respiratory Distress Syndrome and Sepsis?

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Reviewing Author