Multivitamins to Reduce Cardiovascular Mortality: Still No Evidence

Results from a systematic review and meta-analysis of 18 observational and randomized, controlled studies

Many Americans supplement their diets with multivitamins in the belief that these may lower their risks for cardiovascular and other diseases. Unfortunately, multivitamin supplementation has, to date, not been proven to reduce cardiovascular diseases. These researchers performed a systematic review and meta-analysis of studies examining links between multivitamin and mineral (MVM) supplementation and cardiovascular outcomes. The 18 prospective cohort studies (both observational and randomized, controlled trials) were conducted in general populations between 1970 and 2016 and involved 2 million participants and over 18,000 person-years of follow-up.

Only five studies specified the dose and type of MVM supplements, and only two were randomized…

Reviewing Author

Karol E. Watson, MD, PhD, FACC

Disclosures

Consultant/Advisory BoardBoehringer Ingelheim; Amgen; Novartis; Lilly; Amarin

Speaker’s BureauBoehringer Ingelheim

Grant/Research SupportNIH

Editorial BoardsCirculation (Associate Editor)