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Lipoprotein(a) [Lp(a)] is an emerging risk factor for cardiovascular disease (CVD), but little is known about its independent predictive value in CVD risk prediction. To determine the independent association of Lp(a) with incident CVD, researchers used data from the Women's Health Study (n=24,588).
A curvilinear association was found between Lp(a) >50 mg/dL and CVD, but only if total cholesterol was >220 mg/dL. Adding Lp(a) to the Reynolds Risk Score or the American Heart Association and American College of Cardiology's CVD risk prediction equations provided a small but significant improvement in risk prediction; however, it failed to improve reclassification.
The results were validated in another cohort — the Women's Health Initiative (1815 …