Thiamine for Septic Shock?

The metabolic demands of septic shock commonly lead to thiamine deficiency, and thiamine has therefore received attention as an adjunctive therapy for septic shock. In a retrospective single-center cohort study, investigators assessed outcomes in patients in septic shock who received thiamine compared with those who did not.

Patients were identified using ICD codes and chart review to ensure they met Sepsis-3 definitions (lactate >2.0 mmol/L plus vasopressor therapy) at hospital admission. Among 1049 eligible patients, 123 received thiamine and were matched using demographics and measures of disease severity with 246 patients who did not receive thiamine. The main outcome was time to first documentation of lactate clearance; 28-day mortality…