The Challenge of Treating Early HIV Infection: The Seattle Experience

Only 20% of acutely infected patients referred for evaluation were seen while still antibody-negative.

Identifying persons with primary HIV infection can importantly affect transmission networks, an area of high interest for vaccine and eradication efforts. Investigators at the University of Washington have been focused on the earliest stages of infection since 1992. To date, 360 subjects have been enrolled in their observational cohort, of whom 123 with documented very early HIV infection (defined as having enzyme immunoassay (EIA)–negative/RNA-positive results or symptoms consistent with primary infection — Fiebig stages I or II) were referred for further evaluation.

The median time from referral to being seen in clinic was 14 days (13 days for the 114 symptomatic and 21 days for the 9 asymptomatic patients). For the symptomatic patients, t…

Reviewing Author

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

Keith Henry, MD

Disclosures

Consultant/Advisory BoardViiV Advisory Board

Editorial BoardsJAIDS: Journal of Acquired Immune Deficiency Syndromes

The Challenge of Treating Early HIV Infection: The Seattle Experience

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Reviewing Author