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Patients with infectious enteritis are at increased risk for developing irritable bowel syndrome (IBS) after resolution of the acute infection. Glutamine is an essential amino acid and one of its key functions is maintenance of the barrier function of the intestine. Patients with postinfectious IBS diarrhea-predominant (IBS-D) have high prevalence of intestinal hyperpermeability.
In the current double-blinded, randomized, controlled trial (RCT), investigators tested the hypothesis that glutamine supplementation could restore normal intestinal permeability and ameliorate persistent gastrointestinal symptoms in patients with postinfectious IBS-D. One hundred and fifteen patients were randomized to receive 5 g of oral glutamine powder or placeb…