Reassurance About Primary Ovarian Insufficiency After Well-Adolescent Vaccination

Published case series have raised concern about an association between human papillomavirus (HPV) vaccination and the development of primary ovarian insufficiency (POI). In this first population-based epidemiological study, researchers searched Kaiser Permanente Northwest electronic health records from 2006 to 2014 for diagnoses suggestive of POI among nearly 200,000 female patients (ages 11–34 years). The researchers estimated POI incidence and risk after receipt of the following vaccines: HPV; tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis, adsorbed (Tdap); inactivated influenza; and meningococcal conjugate (MenACWY).

The research confirmed 46 idiopathic POI cases. POI incidence was 0.87 per 1,000,000 person-months in y…