Despite early promise with the medication, it does not deliver.
Both animal and human studies have yielded conflicting results as to whether subacute administration of dextroamphetamine enhances the efficacy of physiotherapy on motor recovery. Researchers now report findings from a pilot double-blind study on this treatment that was conducted to refine the target population and determine the appropriate measures for a larger study, among other goals.
The investigators screened 1665 patients and enrolled 64 patients 10 to 30 days after cortical or subcortical ischemic stroke (median age, 66). The study analysis was completed in 2015, although enrollment occurred between 2001 and 2003.
Patients were randomized to 10 mg of dextroamphetamine or placebo, followed by physiotherapy 1 hour later. Treatment occurr…
Reviewing Author
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)
DisclosuresRoyaltiesTextbook of Traumatic Brain Injury, 2nd and 3rd editions
Editorial BoardsUpToDate; Journal of Neuropsychiatry and Clinical Neuroscience
Leadership Positions in Professional SocietiesNorth American Brain Injury Association (Board Member); National Institute on Disability, Independent Living, and Rehabilitation Research (Chair of Data Monitoring Safety Board for study of donepezil on cognition after traumatic brain injury)