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With several evidence-based treatment options for post-traumatic stress disorder (PTSD), which strategy should clinicians choose? To examine how patient preferences might affect treatment outcomes, investigators enrolled 200 patients with chronic PTSD due to various stressors in a 10-week treatment trial; 67% had current axis I comorbidities.
Treatments were prolonged exposure (PE; 90- to 120-minute weekly sessions) or sertraline. After education about rationales for the two treatments, patients were “double-randomized,” first to “choice” (patients selecting their treatment; N=97) or “no choice” (N=103). “No choice” entailed a second randomization to treatment type. There were 155 patients with follow-up data.
At 10 weeks, patients receiving …