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Although consuming long-chain ω-3 polyunsaturated fatty acids (PUFAs) has favorable physiological effects (e.g., on endothelial function), the relation between plasma PUFAs and healthy aging is unknown. In this prospective cohort study, researchers determined the longitudinal association between serial measures of summed and individual plasma PUFAs (i.e., eicosapentaenoic, docosapentaenoic, and docosahexaenoic acid) and α-linolenic acid and healthy aging.
Participants were 2622 elders (mean age, 74) with healthy aging at baseline. Healthy aging was defined as absence of cardiovascular disease, cancer, lung disease, severe chronic kidney disease, and cognitive and physical dysfunction. Plasma PUFA levels were measured three times during the s…