Mortality Risk in Childhood-Onset Inflammatory Bowel Disease

Population-based data show a threefold elevated risk for all-cause death compared with healthy, matched children.

Some data indicate that patients with inflammatory bowel disease (IBD) have an elevated risk for death from all causes as well as certain cancers. However, data in patients whose IBD is diagnosed during childhood are lacking.

Using the Swedish National Patient Registry data, investigators identified 9442 incident cases of IBD diagnosed in patients under age 18 years from 1964 through 2014. Based on 139,000 person-years of follow-up, results were as follows:

There were 259 deaths among people with IBD (133 were from cancer and 54 from digestive disease).
The all-cause mortality rate in these patients was 2.1/1000 person-years, compared with 0.7 in matched reference individuals from the general population.
The average age at death was 61.7 compar…

Reviewing Author

Sunanda V. Kane, MD, MSPH

Disclosures

Consultant/Advisory BoardAbbVie; UpToDate; Spherix Health; Samsung Bioepis

Grant/Research SupportCrohns and Colitis Foundation

Leadership Positions in Professional SocietiesAmerican College of Gastroenterology (Immediate Past President)

Sunanda V. Kane, MD, MSPH

Disclosures

Consultant/Advisory BoardAbbVie; UpToDate; Spherix Health; Samsung Bioepis

Grant/Research SupportCrohns and Colitis Foundation

Leadership Positions in Professional SocietiesAmerican College of Gastroenterology (Immediate Past President)

Mortality Risk in Childhood-Onset Inflammatory Bowel Disease

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Reviewing Author