Inorganic Nitrite to Improve Heart Failure with Preserved Ejection Fraction?

The answer, unfortunately, is no, in a large, placebo-controlled, multicenter trial.

Mechanistic studies suggest that poor nitric oxide (NO) availability plays a role in the pathophysiology of heart failure with preserved ejection fraction (HFpEF). In small short-term studies, inorganic nitrite, which is converted to NO in the presence of hypoxia and acidosis, improved hemodynamics and exercise capacity in individuals with HFpEF. In a multicenter, double-blind trial (NCT02742129), researchers measured the impact of inorganic nitrite in 105 individuals with HFpEF (mean age, 68; 56% women), left ventricular ejection fraction of ≥50%, objective evidence of heart failure, and at least moderate exercise limitation (peak VO₂, <75% predicted). Almost all participants had New York Heart Association class II or III symptoms, and all…

Reviewing Author

Frederick A. Masoudi, MD, MSPH, FACC, FAHA

Disclosures

Consultant/Advisory BoardBristol Myers Squibb; CPC Clinical Research

Grant/Research SupportNational Heart, Lung, and Blood Institute

Editorial BoardsUpToDate; American College of Cardiology Self-Assessment Program (SAP)

Leadership Positions in Professional SocietiesAmerican College of Cardiology (Chair, Innovations Committee)

Frederick A. Masoudi, MD, MSPH, FACC, FAHA

Disclosures

Consultant/Advisory BoardBristol Myers Squibb; CPC Clinical Research

Grant/Research SupportNational Heart, Lung, and Blood Institute

Editorial BoardsUpToDate; American College of Cardiology Self-Assessment Program (SAP)

Leadership Positions in Professional SocietiesAmerican College of Cardiology (Chair, Innovations Committee)

Inorganic Nitrite to Improve Heart Failure with Preserved Ejection Fraction?

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Reviewing Author