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Much has been written about prescribing testosterone for depression in older men. To learn more, European researchers conducted a meta-analysis of 27 randomized, controlled trials (RCTs) involving 1890 men.
All studies compared testosterone with placebo, and one included an antidepressant comparator. Overall, testosterone was associated with a statistically significant but clinically small reduction in depressive symptoms compared with placebo; effect sizes were greater with higher testosterone doses. Only two studies showed strong effects, and baseline testosterone levels did not affect results. Most studies had high or unclear risk of bias and used testosterone as an adjunct to other medications in patients who were given testosterone for …