Fractional-Dose Yellow Fever Vaccination Gives Durable Immune Response

Vaccination with one fifth the usual dose of yellow fever vaccine produces an immune response that lasts at least 10 years in healthy people ≥2 years old.

Recent yellow fever outbreaks and inadequate vaccine supplies prompted use of fractional vaccine doses to prevent spread of yellow fever (NEJM JW Infect Dis Jan 2017 and Lancet 2016; 388:2904). Studies published in 2018 confirmed that a fractional dose is immunogenic in healthy people ≥2 years (NEJM JW Infect Dis May 2018 and N Engl J Med 2018 Feb 14; [e-pub]), but can it provide long-lasting protection similar to full-dose vaccination? To address this question, investigators in the Netherlands followed up on available participants from a trial started 10 years earlier in which 155 participants (age range, 18–70 years) were randomly assigned to receive primary yellow fever vaccination (17D YFV) with 0.1 mL dose intradermally or standard dos…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Fractional-Dose Yellow Fever Vaccination Gives Durable Immune Response

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Reviewing Author