NEJM Journal Watch General Medicine Year in Review 2018

In our annual review of the year's most important clinical research, the editors of NEJM Journal Watch try to balance relevance to general medicine and recognition of landmark studies. This year, our mix of topics differs a bit from previous years: Of the 15 topics, 6 address potentially practice-changing trials in critical care medicine, and 3 address major studies of primary prevention of cardiovascular disease.

Our Year in Review Topics for 2018:

• Aspirin for Primary Cardiovascular Prevention?

• No Value for Routine Vitamin D Supplementation

• Omega-3 Fatty Acid Supplementation for Primary Cardiovascular Prevention?

• Limiting Use of Antipsychotics in Intensive Care Patients

• Stress Ulcer Bleeding Prophylaxis in the Intensive Care Unit

• Steroids for Septic Shock

• Fluid Choice: Balanced Crystalloid Instead of Saline

• Renal Replacement Therapy in the Intensive Care Unit

• Achieving Full Nutritional Goals for Critically Ill Patients Doesn't Change Outcomes

• More Evidence That the “Artificial Pancreas” Is Safe and Effective

• Gene Expression Test Identifies Patients Who Can Skip Chemotherapy

• New Adjunctive Therapies for Coronary Artery Disease?

• Transcatheter Clip for Heart Failure with Mitral Regurgitation

• Advances in Treating Stroke and Transient Ischemic Attack

• Triple Therapy for COPD Patients