Prognostic Value of Cervical HPV when Cytology Is Normal

Among women with normal Pap smears, presence of cervical HPV-16/18 was associated with substantially higher odds of developing CIN2 or worse.

Interpretation of the presence of cervical human papillomavirus (HPV) in the absence of cytological abnormalities continues to evolve. In a nested case-control study, Swedish researchers assessed the odds of developing cervical intraepithelial neoplasia 2 or worse (CIN2+) in women who were HPV positive compared with those who were HPV negative; all 9047 women had normal cervical cytology at baseline. A total of 96 women who developed CIN2+ within 9 years' follow-up were matched with 5 controls (persistently normal cytology) each. All samples were tested retrospectively for baseline HPV status by type.

Any high-risk HPV was detected in 51% of cases and 14% of controls, and HPV-16/18 was detected in 31% of cases and 6% of controls. Among women…

Reviewing Author

Anna Wald, MD, MPH

Disclosures

Consultant/Advisory BoardAicuris; Bayer; GSK; Innovative Molecules; Merck; MAPP Biopharmaceutical (Safety Monitoring Committee)

RoyaltiesUpToDate

Grant/Research SupportNIH/National Institute of Allergy and Infectious Diseases; GSK; Moderna; Assembly Biomedical; Aicuris

Editorial BoardsSexually Transmitted Diseases; Sexually Transmitted Infections; Journal of Infectious Diseases

Leadership PositionsID Division Chiefs Community of Practice (At-Large Member)