Lower Triglycerides to Reduce Cardiovascular Risk? Support from a Genetics-Based Study

Genetic variants associated with both lower triglyceride and LDL levels are associated with a lower risk for coronary heart disease.

Although triglycerides, like LDL, are associated with elevated cardiovascular risks, randomized trials of triglyceride lowering have yielded inconsistent evidence of benefit. Because both LDL and triglycerides are lipoproteins containing apolipoprotein B (apoB), these investigators used mendelian randomization analyses to compare the associations of triglyceride-lowering genetic variants and LDL-lowering genetic variants with cardiovascular risk as a function of unit change in apoB. Using data from 63 cohort, cross-sectional, or case-control studies conducted in North America or Europe (N=654,783; mean age, 63; 51% women), the investigators developed genetic risk scores of triglyceride-lowering variants in the lipoprotein lipase gene (LPL) …

Reviewing Author

Karol E. Watson, MD, PhD, FACC

Disclosures

Consultant/Advisory BoardBoehringer Ingelheim; Amgen; Novartis; Lilly; Amarin

Speaker’s BureauBoehringer Ingelheim

Grant/Research SupportNIH

Editorial BoardsCirculation (Associate Editor)

Karol E. Watson, MD, PhD, FACC

Disclosures

Consultant/Advisory BoardBoehringer Ingelheim; Amgen; Novartis; Lilly; Amarin

Speaker’s BureauBoehringer Ingelheim

Grant/Research SupportNIH

Editorial BoardsCirculation (Associate Editor)

Lower Triglycerides to Reduce Cardiovascular Risk? Support from a Genetics-Based Study

Topics

Reviewing Author