WHO Hepatitis C Targets May Be Achievable Only with Combined Interventions

A mathematical-model study suggests that a strategy combining multiple interventions could prevent 1.5 million HCV-related deaths by 2030 but would require expanded hepatitis services and substantial resources.

The availability of direct-acting antivirals for hepatitis C virus (HCV) has raised the possibility of global elimination. The World Health Organization (WHO) has established targets that include 65% reduction in HCV-related mortality and 80% reduction in incidence by 2030. Are these goals feasible?

Investigators developed a mathematical model to project the impact of potential interventions in 190 countries. The model incorporated data on demography, injection-drug use, HCV prevalence, current prevention and treatment programs, natural history of HCV infections, and HCV-attributable mortality. They estimated HCV cases and deaths over time and projected outcomes with sequential addition of four interventions: blood safety and infection contr…

Reviewing Author

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

Mary E. Wilson, MD

Disclosures

Consultant/Advisory BoardOneHealthTrust (formerly Center for Disease Dynamics, Economics, and Policy); Global Health Institute, University of Wisconsin

RoyaltiesUpToDate

Editorial BoardsJournal of Travel Medicine

WHO Hepatitis C Targets May Be Achievable Only with Combined Interventions

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Reviewing Author