Cortical Superficial Siderosis Is Associated with Worse Outcomes in Patients with Cerebral Amyloid Angiopathy

Cerebral amyloid angiopathy (CAA) is an important cause of lobar intracerebral hemorrhage. Other radiographic findings associated with CAA such as cerebral microhemorrhages and cortical superficial siderosis — which are the result of chronic superficial hemorrhages into the subarachnoid space along the convexities — are important diagnostically but likely have prognostic value as well. Because incidence of both CAA and atrial fibrillation increases with age, and because bleeding risk increases with CAA and thromboembolic risk increases with atrial fibrillation, the stakes for optimizing antithrombotic management are particularly high. Understanding how these radiographic findings influence hemorrhage risk could provide for more individualiz…