AF Associated with Long-Term Mortality in Degenerative Mitral Regurgitation

Surgery improved survival, but both paroxysmal and persistent atrial fibrillation were associated with excess late mortality.

Atrial fibrillation (AF) is a class IIa indication for surgery in patients with severe degenerative mitral regurgitation (DMR). To learn about mortality in these patients, researchers identified 2425 patients in an international, severe DMR registry, classified them based on their cardiac rhythm at diagnosis, and followed them for a median of 9 years.

Patients with paroxysmal AF (13%) or persistent AF (19%) were older and more likely to be symptomatic than patients in sinus rhythm. Overall, 1889 patients (78%) eventually underwent surgery, 1463 (60%) within 6 months of diagnosis. Estimated 10-year survival rates were 74%, 59%, and 46% for patients with sinus rhythm, paroxysmal AF, and persistent AF, respectively. Early surgery was associated…

Reviewing Author

Howard C. Herrmann, MD

Disclosures

Consultant/Advisory BoardAffluent Medical; Artedrone; Caranx; Johnson & Johnson; Medtronic; Prolifagen; Wells Fargo

EquityMicrointerventional Devices, Inc.

RoyaltiesUniversity of Pennsylvania

Grant/Research SupportAbbott Vascular; Edwards Lifesciences; Johnson & Johnson; Medtronic

Editorial BoardsCatheterization and Cardiovascular Interventions; Journal of the American College of Cardiology; Circulation: Cardiovascular Interventions; JACC Cardiovascular Interventions; JACC Case Reports; JSCAI

Leadership Positions in Professional SocietiesHeart Valve Collaboratory (Scientific Committee Member, Chair of the Publications Committee)