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Endoscopic mucosal resection (EMR) can effectively eradicate large colorectal polyps but is associated with a high residual neoplasia rate (about 20%). Endoscopic assessment and biopsy of EMR scars, and treatment of any residual neoplasia, are indicated at surveillance colonoscopy within 6 months. Imaging technologies for the optical diagnosis of polyp histology could be used to assess EMR scars and direct biopsy and resection decisions, but they have not been validated for this purpose.
In a prospective study, five expert endoscopists conducted real-time assessment of 255 EMR scars of polyps ≥20 mm. Examinations were done sequentially with white-light colonoscopy alone and then with near focus, followed by narrow-band imaging (NBI) alone an…