Following stem cell transplantation for lymphoma, a person with HIV has not had viral rebound despite stopping antiretroviral therapy.
The “Berlin patient” was cured of HIV after receiving a stem cell transplant from a donor who lacked the HIV coreceptor CCR5 (homozygous CCR5Δ32/ Δ32). Now, investigators report the outcome of a person with HIV who underwent stem cell transplantation for lymphoma.
The person was diagnosed with HIV in 2003 but did not initiate antiretroviral therapy (ART) until 2012. Later that year, he was diagnosed with stage IV Hodgkin lymphoma and required multiple rounds of salvage chemotherapy to achieve remission. In 2016, he underwent stem cell transplantation from a homozygous CCR5 Δ32/Δ32 donor. His posttransplant course was complicated by Epstein-Barr virus reactivation, for which he received rituximab, and mild graft- versus-host disease. After th…
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DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)
DisclosuresGrant/Research SupportNIH
Editorial BoardsUpToDate; ID Images (idimages.org); Infectious Diseases Society of America COVID-19 Treatment Guidelines; International Antiviral Society–USA (Guidelines Committee)
Leadership Positions in Professional SocietiesHIV Medicine Association; Infectious Diseases Society of America (Board of Directors)