Characterizing Cervical Spine Lesions in Multiple Sclerosis

Spinal cord lesions may be diagnostic and prognostic in MS.

The cervical spine is an eloquent region of central nervous system tissue that is frequently involved in multiple sclerosis (MS). To further characterize the spatial characteristics of MS cervical spine lesions and correlate lesion burden with clinical status, investigators conducted a retrospective, multicenter study involving 642 adult MS patients with primary progressive MS (PPMS), secondary progressive MS (SPMS), relapsing-remitting MS (RRMS), or clinically isolated syndrome (CIS).

Results were as follows:

Cervical spine lesions were identified in 99% of PPMS patients, 95% of SPMS patients, 90% of RRMS patients, and 77% of CIS patients.
Lesion counts were higher in PPMS and SPMS patients than in RRMS patients or CIS patients.
Lesions in whi…

Reviewing Author

Robert T. Naismith, MD

Disclosures

Consultant/Advisory BoardAlexion Pharmaceuticals; Amgen; Astoria; Biogen; Bristol Myers Squibb; Celltrion; Genentech; Hoffmann-La Roche; Genzyme; EMD Serono; Immpact-Bio; Immunic Therapeutics; Kyverna; Lundbeck; Novartis; Sandoz; TG Therapeutics

Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense

Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)

Robert T. Naismith, MD

Disclosures

Grant/Research SupportNational Institutes of Health; National Multiple Sclerosis Society; U.S. Department of Defense

Leadership Positions in Professional SocietiesConsortium of Multiple Sclerosis Centers (Treasurer)

Characterizing Cervical Spine Lesions in Multiple Sclerosis

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Reviewing Author