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Multiple trials have demonstrated the benefits of thrombectomy for large vessel occlusion stroke, but patients with significant early brain infarction on initial neuroimaging were largely excluded from these studies. Therefore, in current American Heart Association guidelines, recommendations for stroke thrombectomy are limited to patients without extensive early infarction (Alberta Stroke Program Early Computed Tomography [ASPECTS] score >5), reflecting the uncertainty about the potential benefits or harms of thrombectomy for patients with more-extensive infarction. To shed light on the potential risks and benefits of thrombectomy in the latter patients, investigators reviewed registry data from three high-volume stroke centers and identif…