Loading...
After initial antibiotic treatment for Lyme borreliosis, a small subset of individuals develops persistent symptoms including fatigue, cognitive dysfunction, and pain. The causes of such symptoms remain unclear, and the benefit of repeated or long-term antibiotic therapy remains unproven. A previous placebo-controlled, double-blind, randomized clinical trial, the PLEASE (Persistent Lyme Empiric Antibiotic Study Europe) study, showed no difference in health-related quality of life between individuals treated with 2 weeks of intravenous (IV) ceftriaxone alone versus IV ceftriaxone plus 12 weeks of either oral doxycycline, clarithromycin-hydroxychloroquine, or placebo. Here, PLEASE investigators performed a preplanned analysis of cognitive per…