Vitamin D Cancer Therapy?

Vitamin D₃ supplementation, compared with placebo, did not result in significant improvement in relapse-free or progression-free survival in two new trials.

Population-based studies and retrospective analyses suggest that higher levels of serum 25-hydroxyvitamin D₃ are associated with lower cancer incidence and cancer mortality and may correlate with improved outcomes in metastatic colorectal cancer (e.g., J Natl Cancer Inst 2019; 111:158 and BMC Cancer 2010; 10:347)

Now, to examine whether vitamin D₃ supplementation can improve outcomes in patients with cancer, two teams of investigators have conducted prospective randomized trials involving patients with digestive-tract cancers treated curatively and those with metastatic colorectal cancer treated with palliative chemotherapy.

Urashima and colleagues report the results of a multicenter, randomized, controlled, double-blind, phase III trial (AMA…

Reviewing Author

David H. Ilson, MD, PhD

Disclosures

Consultant/Advisory BoardAstraZeneca; Merck; Taiho; Astellas; Bristol Myers Squibb; Regeneron; Oncolys; Amgen; Daiichi Sankyo

David H. Ilson, MD, PhD

Disclosures

Consultant/Advisory BoardAstraZeneca; Merck; Taiho; Astellas; Bristol Myers Squibb; Regeneron; Oncolys; Amgen; Daiichi Sankyo

Vitamin D Cancer Therapy?

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Reviewing Author